The department Guyane has 22 communes.
| Code | Name | Population ▼ |
|---|---|---|
| 97302 | Cayenne | 62 675 |
| 97311 | Saint-Laurent-du-Maroni | 54 429 |
| 97307 | Matoury | 36 512 |
| 97309 | Remire-Montjoly | 27 723 |
| 97304 | Kourou | 24 824 |
| 97305 | Macouria | 19 899 |
| 97306 | Mana | 10 957 |
| 97360 | Apatou | 10 306 |
| 97357 | Grand-Santi | 9 668 |
| 97353 | Maripasoula | 9 579 |
| 97362 | Papaichton | 5 006 |
| 97308 | Saint-Georges | 4 915 |
| 97313 | Montsinéry-Tonnegrande | 3 626 |
| 97310 | Roura | 3 449 |
| 97312 | Sinnamary | 2 756 |
| 97356 | Camopi | 2 189 |
| 97303 | Iracoubo | 1 662 |
| 97301 | Régina | 1 658 |
| 97361 | Awala-Yalimapo | 1 577 |
| 97352 | Saül | 277 |
| 97358 | Saint-Élie | 159 |
| 97314 | Ouanary | 150 |