This region has 22 communes.
| Code | Name | Population |
|---|---|---|
| 97302 | Cayenne | 62 675 |
| 97311 | Saint-Laurent-du-Maroni | 54 429 |
| 97307 | Matoury | 36 512 |
| 97309 | Remire-Montjoly | 27 723 |
| 97304 | Kourou | 24 824 |
This region has 3 arrondissements.
| Code | Name | Administrative seat |
|---|---|---|
| 9731 | Cayenne | Cayenne |
| 9732 | Saint-Laurent-du-Maroni | Saint-Laurent-du-Maroni |
| 9733 | Saint-Georges | Saint-Georges |
This region has 1 departmental collectivity.
| Code | Name | Administrative seat |
|---|---|---|
| 973R | Collectivité territoriale unique de La Guyane | Cayenne |